Originally Posted on November 20, 2013, by Heather Hershey And, might I add, hormones are also a huge pain in the you-know-what! I was out of my prescriptions for spironolactone - a.k.a. aldactone - and metformin and lazy about refilling them for about a week. Both of these pills are commonly prescribed to ladies with PCOS. The metformin controls two things: the amount of glucose created in the liver that is pumped into the bloodstream and the sensitivity of body tissues to that glucose. Aldactone is a water pill that helps with bloat, but is also a testosterone antagonist, meaning that it minimizes the impact of androgens in women with PCOS related acne and hair loss. So, if you can imagine, this was a generally bad lapse in judgment on my part. I had epic cravings and epic bloat for that entire week. I returned right back to my original powerful lust for refined sugar. (It certainly doesn't help that everything pumpkin is in season right now. I never met a pumpkin spice cake I didn't like. Cream cheese frosting? UMDUHYESPLEASE.) I could feel myself getting puffier. I gained nine pounds in one week. This sounds really impressive, but I wasn't eating any more than usual calorically. I WAS, however, eating a sh'load more carbs than I normally do. This was clearly a big problem (no pun intended). I filled my script and began taking my meds again STAT. I lose five pounds in two days! This is an even more impressive finding. My tummy is flatter and the cravings are completely gone. The moral of this story is: Remember to fill your PCOS prescriptions early and, if they are working for you, keep taking them.